Polynucleotides in Marylebone, London
Injectable polynucleotides — purified salmon DNA fragments that bind water and stimulate collagen and elastin. Used for skin quality (under-eye, face, neck) and for early-stage hair regeneration.
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Polynucleotides are purified short fragments of salmon DNA — a bioactive substance that binds water in tissue, stimulates fibroblasts to produce new collagen and elastin, and has documented anti-inflammatory effects. They are not a filler (no volume) and not a bioremodeller of the Profhilo class (different mechanism); they sit in a third regenerative category, particularly useful for skin where structural filler is the wrong tool — under-eye texture, periorbital crepiness, fine perioral lines — and for early-stage androgenetic hair loss as a non-surgical alternative or adjunct to PRP. The standard protocol is three sessions roughly three weeks apart for the initial course, followed by maintenance.
Key benefits
- Regenerative — stimulates your own collagen, elastin, and hyaluronic acid production
- Strong evidence for under-eye texture, fine lines, and skin quality
- Hair-growth indication: early-stage androgenetic alopecia in men and women
- Different mechanism from filler and from Profhilo — frequently combined with both
- Standard protocol: 3 sessions 3 weeks apart, then maintenance
- Suitable across all Fitzpatrick phototypes
Clinical detail
Transparent, all-in pricing
Skin
Hair
FAQ
Common
questions
How long until I see results from polynucleotides?
For skin indications, change starts to be visible from session 2 (around week 3) and peaks 8 to 12 weeks after session 3. For hair, change is slower because hair growth cycles are slow — visible improvement from month 3 to 4, peak from month 6 to 9. Photos are taken at baseline and at every appointment so progress is documented even when day-to-day change is hard to see in the mirror.
Do polynucleotides hurt?
For skin indications, discomfort is mild — a small pinch at each injection point, with topical numbing cream applied for 15 minutes beforehand. For scalp hair treatment, the scalp is more sensitive; a finer needle and slow injection technique reduce discomfort, and most patients describe it as 3 to 5 out of 10. The procedure takes 20 to 30 minutes per session.
How do polynucleotides differ from PRP?
Both are regenerative injectable treatments, but PRP (platelet-rich plasma) uses your own blood (drawn, spun, re-injected) and varies by individual; polynucleotides use a standardised, MHRA-compliant pharmaceutical product that delivers a consistent dose every session. PRP is biologically rich but variable; polynucleotides are biologically narrower but predictable. Many clinicians prefer polynucleotides for that consistency, particularly in hair indications.
Are there side effects?
The most common: small bruise at injection points (15% of treatments, resolves 3 to 5 days), mild local swelling for 24 hours, and brief tenderness at the scalp for hair treatment. Rare: localised redness or small lump at an injection point that resolves over 1 to 2 weeks. Polynucleotides have a strong safety profile because they are biologically similar to the body's own building blocks.
How often should I have maintenance?
For skin: a single booster session every 4 to 6 months keeps the regenerative effect topped up. For hair: a maintenance session every 4 to 6 months. Some patients combine polynucleotides with their existing skincare or hair-loss regimen (topical retinoids, oral finasteride, minoxidil) and find the maintenance interval lengthens further.
Can I combine polynucleotides with other treatments?
Yes. Polynucleotides are commonly combined with HA filler (different mechanism, complementary effect), Profhilo (also complementary), and toxin (different target tissue entirely). Energy-based treatments (laser, microneedling) should be spaced 2 weeks either side. The most common combination at this clinic is polynucleotides under-eye plus tear-trough filler at a separate appointment.
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Dr Oli Aesthetics • 1 Orchard Street, UNTIL Marylebone, London W1H 6HJ
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